The Effects and Role of Different Exercise Modalities on AMP-Activated Protein Kinase (AMPK) Activity: A Review of Underlying Mechanisms
DOI:
https://doi.org/10.5281/zenodo.18256687Keywords:
exercise, Exercise Metabolism, mTORAbstract
AMP-activated protein kinase (AMPK) is a central regulator of cellular energy homeostasis and plays a critical role in metabolic adaptation to exercise. During skeletal muscle contraction, increases in the AMP/ATP ratio activate AMPK signaling pathways, promoting glucose uptake, fatty acid oxidation, and mitochondrial biogenesis while inhibiting energy-consuming anabolic processes. These molecular adaptations contribute to improved metabolic health and reduced risk of chronic diseases such as obesity, type 2 diabetes, and cardiovascular disorders. In addition, the interaction between AMPK and the mammalian target of rapamycin (mTOR) pathway represents an important mechanism explaining the distinct adaptations to endurance and resistance training. Endurance exercise predominantly activates AMPK-mediated metabolic pathways, whereas resistance training stimulates mTOR-dependent protein synthesis and muscle hypertrophy. Therefore, understanding the molecular interaction between these pathways is essential for optimizing both athletic performance and metabolic health. This review aims to summarize the structure and function of AMPK, its role in exercise metabolism, and its potential implications in the prevention and treatment of metabolic diseases.
Keywords: AMPK, Exercise Metabolism, mTOR
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